On Wednesday, the 29-year-old will be playing in his first Wimbledon quarter-final since 2013, when he went on to lose to Novak Djokovic in an epic semi-final.
Rodina left the court for a few minutes at the end of the first set but when she returned Williams continued her domination with an early break in the second.
Serena Williams survived a scare to reach the Wimbledon semi-finals with a comeback victory over hard-hitting Italian Camila Giorgi.
Williams stepped up to the line at 5-4 and brought up match point with an ace before completing victory when Giorgi could only push a forehand into the net.
Though she was able to halt Williams' momentum and a run of four successive games, Giorgi could not prevent her from forcing a third set, the 36-year-old letting out a huge roar as she clinched the second.
Having shaken off any rust that may have remained from her absence, Williams appears to be closing in on top form at the right time.
However, Williams lifted her intensity to level, before closing out the match to move a step closer to reclaiming the title she won in 2016.
"It wasn't as tight as I was used to", she said last month. I just kept fighting.
The American then cruised through the deciding set with a single break of serve enough to ensure her place in the semi-finals.
"I'm ok, I feel good, I feel like I did better today, I had to".
But the title favourite is seven-time champion Serena Williams, seeded 25th after her lengthy maternity leave, and due to face Russian qualifier - and fellow mother - Evgeniya Rodina later on Monday.
The professional tennis player is competing in the quarter finals of the competition, with Drizzy Drake cheering her on in the stands. But this is only my fourth tournament back (so) I don't feel pressure, I don't feel like I have to win this. "I feel like I'm back, but I still have a long way to go to get to where I was". The number 11 seed overcame a determined Belinda Bencic 6-3, 7-6 and, like Görges, will fancy her chances at upsetting Williams' charge to the title.