Messi's side were kicked out the World Cup following their loss to France earlier today; with many people speculating that it could be Messi's and Ronaldo's last ever World Cup.
Uruguay coach Oscar Tabarez, however, said it was too early to determine the specifics of Cavani's injury.
That doesn't sound like a player who is ready to give up on what has been a life-long World Cup dream and Ronaldo insisted he has enjoyed Russian Federation 2018 despite the outcome for his team.
From it, Portugal were level as Pepe stormed in to head home from Guerreiro's delivery and grab the goal that they had increasingly threatened since the break. "You don't prepare a match just looking at one player".
Like Messi, Ronaldo has never scored in a knockout round match at the World Cup. And if Uruguay can lock out Ronaldo again and send European champions Portugal home, Godin will surely have a lot to do with it.
Pepe gave Portugal some hope when he found the equaliser in the 55th minute.
Portugal's Ronaldo has scored 85 goals in 153 appearances and looks in inspiring form, the last group game where he missed a penalty and was involved in a VAR-influenced decision getting away with a yellow card after pulling down an Iran defender.
And after Portugal equalised on Pepe's header in the 55th minute, it was Cavani again finishing a flawless Uruguay counter in the 62nd with a shot from just inside the penalty area that caught Portugal goalkeeper Rui Patricio slightly out of position and curled inside the far post.
The fearless Uruguay go marching on: The South Americans remain "dark-horses" for World Cup glory, but with four wins out of four, conceding just one goal in the process, they simply can not be overlooked.
The quarter-final match between Uruguay and Portugal will take place in Sochi on Sunday (4am AEST). Next up for the underdogs is France and if they can snatch the first goal, their defence could see them through to the final four. But the Real Madrid superstar has been at the heart of much of what went right for Portugal at this World Cup.
"It's not just in this World Cup that they have not been conceding goals - it has been like that for the whole of 2018". It didn't take long for Uruguay to respond though with another Suarez to Cavani play marking their second of the day and giving their squad the win.