The US firm has acquired the rights to livestream 20 matches a season for three years, starting in August 2019.
After the past two domestic deals both produced 70 percent jumps in the value of rights, the league is now experiencing a downturn and looking to generate more revenue overseas where all 380 games are available live each season.
Specifically, the vast online retailers will show one entire round of midweek matches in early December and one round of matches over the Christmas bank holiday. Sky won four of the five "best deals", with BT taking the other.
The agreement gives Amazon a package of 20 matches per season from the league.
Amazon memberships costs £79 annually - and they also offer a £7.99 a month package. BT's deal means that BT Sport will, for the first time, show multiple mid-week Premier League matches on the same evening.
Amazon is no stranger to live sport.
Pescatore added that the award was "great news for BT, with its TV platform the only place where users can watch all the Premier League matches from 2019, thanks to its content relationships with Amazon and Sky - for Now TV".
Amazon's Jay Marine said Prime members in Britain would be able to watch every team and every game in the two rounds of fixtures, "so no matter which Premier League team you support, you're guaranteed to see them play live on Prime Video".
Facebook made a major bid previous year to stream cricket matches from the Indian Premier League and is streaming Major League Baseball games, while Twitter has streamed baseball and professional hockey games.
However, analysts said they probably did not sell in February because they did not achieve the reserve price set by the Premier League.
The Premier League is easing into doling out fixtures to streaming video.
The way Premier League rights are sold in the United Kingdom is complicated and not all games are available for broadcast.
In future less of your Premier League viewing habits will be satisfied through a standard Sky Sports television subscription.
The deal underlines Amazon's ambition to take on traditional pay-TV broadcasters in the multi-billion dollar battle for sports rights.
The deal will expand awareness of Amazon Prime, the company's lucrative subscription service.
In contrast, the Premier League will be delighted with this outcome after having secured a leading online giant.