"He's untouchable, you need to understand that and try to create situations in training that fit around him and from there pick a side with a view to that", Sampaoli told a news conference on Monday.
"It is impossible to teach him anything". We have a debt with ourselves (the players). "We never, at any point, think about risking him". Speaking ahead of Spain's encounter against 2014 World Cup finalist, David de Gea feels it will be better if both teams feature a competitive line-up at Wanda Metropolitano.
Nevertheless, the occasionally feisty nature of their Clasico showdowns does not give Sampaoli any cause for concern over Messi's fitness.
Despite Dybala's superb talent, the Juventus striker may miss out on World Cup selection.
"Before the game against Italy, Leo said he could not play".
Last year, the Juve man admitted that he and Messi have not quite worked out how to play alongside one another, as they generally play in the same position for their respective clubs.
"He was tested yesterday and tried again today".
Spain drew 1-1 with Germany in their previous friendly outing.
"I was left with the choice to play against Italy and didn't, but I trained normally, I felt good, so I hope to play". On the right we can cut in and have the whole pitch in front of us.
"To see what will make us work like a team", admitting that while Argentina still had work to do to decide their strongest side, "Spain have their side already consolidated. if they are not the best side in the world, they are among the best".
"It's more hard for us to play there, I don't often go out to the left".