Now, Zuma faces being ousted by Ramaphosa and the party's National Executive Committee (NEC) - just as he himself ousted then-President Thabo Mbeki in 2008, after defeating Mbeki for the presidency of the ANC in 2017.
After a 13-hour meeting of the ANC's leadership, the party's secretary-general on Tuesday said Zuma should resign promptly and that a response is expected from the president on Wednesday.
Zuma's second and final presidential term would have expired in 2019 anyway, but it looks like his party wants to show him the door early.
Zuma's nine years as President of South African has been marred by allegations of massive corruption and this has undermined the image and legitimacy of ANC.
"Should Zuma fail to resign, the NEC will have to decide whether to bring a motion of no confidence in Zuma to the parliament", said a legal expert who spoke on condition of anonymity.
Opposition parties, such as the Democratic Alliance are now calling for parliament to be dissolved in addition to Zuma stepping down. "The decision has been taken and must be implemented".
At the time, Ramaphosa cancelled an emergency urgent NEC meeting that was called for last week Wednesday in Cape Town, describing his talks with Zuma as "fruitful and constructive".
If he refuses to quit, the ANC will be forced into the ignominious choice of siding with the opposition in a vote of no confidence in parliament, or put forward a motion of its own.
The meeting, which was scheduled to begin at 2 pm on Monday, is widely expected to finalise the fate of Zuma, who has previously refused his party's requests to step down.
South Africa is set to hold a presidential election next year.
South Africa's ruling party has chose to sack Jacob Zuma as the country's president, a senior official says.
We can no longer keep South Africa waiting, said senior ANC official Paul Mashatile.
Zuma has, nonetheless, withstood the scandals and opposition parties' repeated attempts to remove him.
The deputy in question was Jacob Zuma, who took over the presidency the following year.
Signs of law enforcement mobilizing against the Guptas, and by association Zuma, caused the rand to strengthen 0.5 per cent against the dollar.
As the Gupta-linked investigation proceeds, Zuma also could face corruption charges tied to an arms deal two decades ago.
In 2016, South Africa's highest court ruled that Zuma violated his oath of office when he used an estimated $15 million of government money to upgrade his private home.