To be a successful activist lawyer, she once noted, one must "have an eye for what's hot, the right case, the right bench".
She was again put under house arrest in November 2007 after the imposition of emergency rule in Pakistan. Her other daughter, Salima, lives in London.
In 2007, Pervez Musharraf, then a general, also put her under house arrest as the country's lawyers and politicians began a movement to restore democracy.
She co-founded the Human Rights Commission of Pakistan in 1987.
Subsequently, Jahangir went on to become the first woman to serve as president of the Supreme Court Bar Association of Pakistan. Pakistan has lost a passionate champion of human rights and a staunch supporter of democracy.
And Adil Najam, the Dean of the Pardee School of Global Studies at Boston University tweeted she "was not just the voice of our collective conscience".
However, there were some who termed her a hypocrite, a traitor - posting a picture of her receiving an award from Bangladesh Prime Minister Sheikh Hasina - and even an "Indian agent".
While presenting her report to the Human Rights Council, she was interrupted by a furious Syrian representative who assailed her at the behest of the Iranian regime. "We are waiting for our relatives to return to Lahore", her daughter Munizae Jahangir said in a tweet.
"Asma Jahangir struggled for human rights and democracy", said Zardari.
"She was and will remain an inspiration".
Jahangir secured a number of victories during her life, from winning freedom for bonded labourers from their "owners" through pioneering litigation, to a landmark court case that allowed women to marry of their own volition.
Jahangir had participated in the Movement for the Restoration of Democracy and protested against former Pakistan President Zia-ul-Haq's oppressive military rule.
She won numerous national and global awards for her struggle for the oppressed.
In recent years, she was outspoken over the misuse of blasphemy laws that carry the death sentence. Asma Jehangir's death is a great loss of Pakistan.
Asma Jahangir passed away earlier today in a Lahore hospital at the age of 66 after suffering a cardiac arrest.
She received several awards, including a Hilal-i-Imtiaz and a Sitara-i-Imtiaz in 2010.