But her most interesting moment in the interview came when she called Donald Trump a "fu*king stupid person", a brief correction from what she initially called the 45th President of the United States.
Nolan was talking to Desus Nice and The Kid Mero about Trump's thumbs-up hand gesture, which has apparently inspired white supremacists to copy him.
Nolan, 30, then asked to "back it up" and instead called Trump a "f***ing stupid person".
The Nolan brouhaha is just the latest in a litany of bad press for the sports network.
"I'm on a lot of meds right now", she said on the show immediately after blurting out the insult. Since joining ESPN, she has appeared on shows such as "Highly Questionable" with Dan Le Batard and one episode of a podcast that has yet to be officially named. After sharing her thoughts about her new role at ESPN, where she's only been since last October after four years with Fox Sports, the topic quickly switched to Trump.
The revamped guidelines say employees "should refrain from overt partisanship or endorsement of particular candidates, politicians or political parties" while avoiding "personal attacks and inflammatory rhetoric".
In October, before the new guidelines were released, ESPN suspended "SportsCenter" personality Jemele Hill for what the network deemed a second recent violation of its former social media policy.
O'Neill also ripped ESPN boxing commentator Max Kellerman for declaring that the Houston Astros baseball team made a "grave error" in accepting a White House invitation.