There had been rumours that Bryan left because of ongoing disagreements with leading star Rami Malek, though the director insisted that any dispute between them has been sorted out.
THR reported that Singer was absent during production on several occasions.
Despite being over a year away, one of next year's most anticipated movies was quickly pegged to be already Bryan Singer's Bohemian Rhapsody.
"Bryan Singer is no longer the director of Bohemian Rhapsody", the studio said in a statement provided to The Hollywood Reporter.
In one particularly tense moment, Malek - who's playing Freddie Mercury - got into an altercation in which Singer threw an object.
With just over two weeks of principal photography left to wrap up the film, Fox may tap an insider to complete it rather than seek an outside director.
Additionally, the actor, Tom Hollander, quit the movie for a moment due to Singer but eventually came back to portray the manager of Queen, Jim Beach. There was also apparently an incident that a cinematographer had no choice but to step in to take on the directing duties because Singer did not show up on set at all.
It wasn't until after Thanksgiving when Singer failed to return to set and is believed to have been in the US for the last ten days.
Rami Malek is starring as the legendary frontman Freddie Mercury in the movie that had been filming in London. It was at this time Fox chose to fire him under his pay-or-play contract. Fox says they're going to be announcing a replacement very soon. "Bohemian Rhapsody" is now slated for a release date of December 25, 2018.
This might appear to be a shocking turn of events given Singer's good relationship with Fox where he previously shot the successful X-Men: Days of Future Past and X-Men: Apocalypse back-to-back. Another source said that about two weeks of shooting remain to complete the movie, which may result in the studio turning to a member of the current crew such as Sigel to complete the film rather than bringing in a new director from the outside.