It is at least the third Weinstein case that police in NY have examined.
"I did say no, and when he was on top of me I said, 'I don't want to do this, '" de la Huerta told Vanity Fair.
The actress's claims are very similar to ones shared by many among the more than 60 women who have come forward accusing Weinstein of assault, harassment, or rape.
Paz de la Huerta, who appeared in the Boardwalk Empire series, spoke to Vanity Fair about her claims.
Speaking at a news conference at Police Headquarters in Lower Manhattan on Friday afternoon, officials told The New York Times they were gathering evidence with an eye toward preparing a warrant to arrest Weinstein, whose representatives have said is undergoing therapy outside of New York.
The 33-year-old met the disgraced Oscar victor at a party in October, 2010, and the pair shared a ride home together, she told CBS News.
The first instance, de la Huerta said, was in November of that year. "No doubt", Boyce said.
As the scandal widens, police in Britain are now investigating an allegation of sexual assault by actor Kevin Spacey. Either way, they need collaboration from Manhattan prosecutors, who put the brakes on a 2015 investigation into Weinstein.
Investigations amid mounting allegations against Weinstein are taking place in Los Angeles and the United Kingdom. A Weinstein spokesperson has "unequivocally denied" any accusations of non-consensual sex.
He said the NYPD was working on the case with the Manhattan district attorney's office.
According to the Times, "The theater had agreed to reimburse Mr. Weinstein and other investors for a $1.25 million payment and $500,000 charitable contribution toward the show if they could get third parties to donate those amounts, according to records of the arrangement". We are not the target, but of course we are cooperating fully.